![]() Synaptophysin: positive at least focally in the majority of medulloblastomas.Anaplasia with marked nuclear pleomorphism, high mitotic count and apoptotic counts.Large cell / anaplastic medulloblastoma:.Expanded lobular architecture as reticulin free nodular zones are enlarged and rich in neuropil-like tissue.Medulloblastoma with extensive nodularity:.Densely packed, undifferentiated cells with hyperchromatic and pleomorphic nuclei, which produce dense intercellular reticulin fiber network with nodular reticulin free zones.Desmoplastic / nodular medulloblastoma:.Syncytial arrangement of densely packed undifferentiated cells (embryonal cells).SHH activated medulloblastomas can present with any of these histologic phenotypes however, desmoplastic / nodular and extensive nodularity histologic patterns invariably fall into this molecular subtype.Medulloblastomas in general have 4 distinct histologic patterns: classical, desmoplastic / nodular, medulloblastoma with extensive nodularity and large cell / anaplastic. ![]()
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